Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
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Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
Repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc) through an unknown mechanism. Furthermore, glial cells in the NAc are activated by drugs of abuse, but the contribution of glia to the development of addictive behaviors is unknown. Tumor necrosis factor alpha (TNF-α)...
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ژورنال
عنوان ژورنال: Neuron
سال: 2016
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2016.03.030